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Annals of Family Medicine Podcast

Ep. 8: Body Mass Index vs Body Fat Percentage as a Predictor of Mortality in Adults Aged 20-49 Years feat. Arch G. Mainous III, PhD, and Frank A. Orlando, MD (Vol. 23 Iss. 4)

19 Aug 2025

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In this episode, researchers Arch G. Mainous III, PhD, and Frank A. Orlando, MD, discuss their recently published study, “Body Mass Index vs Body Fat Percentage as a Predictor of Mortality in Adults Aged 20-49 Years." The study found that body fat percentage is a stronger predictor of 15-year mortality risk among U.S. adults than body mass index (BMI). Although BMI is widely used in clinics as the standard measure of body composition, it can potentially misclassify muscular individuals as overweight and miss cases of "normal-weight obesity," masking serious metabolic and heart disease risks. The study findings support reexamining how body composition is measured in clinical settings.   Other studies mentioned in the episode: 2016 study: "Prevalence of Prediabetes and Abdominal Obesity Among Healthy-Weight Adults: 18-Year Trend 2022 study: Body fat and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies  

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